Use of Neuroprotective Drugs and Ultrasound Modulation for Combined Intervention of Parkinson's Disease

讲座名称：Use of Neuroprotective Drugs and Ultrasound Modulation for Combined Intervention of Parkinson's Disease

讲座人：袁振 教授

讲座时间：6月30日16:30-18:30

讲座地点：长安校区会议中心103报告厅(保铮报告厅)

讲座人介绍：

袁振，博士，现为澳门大学健康科学学院教授、认知与脑科学研究中心主任及协同创新研究院副院长。他曾先后在中国科学技术大学获得博士学位，并在新加坡国立大学、克莱姆森大学及佛罗里达大学从事博士后或研究助理教授工作，后历任亚利桑那州立大学助理教授、澳门大学助理教授、副教授，于2021年起任现职。其研究聚焦生物医学光子学、光学分子影像及脑功能成像，已发表SCI论文300余篇，H指数56，引用近万次，并兼任多个学会理事及期刊副主编。

讲座内容：

To date, non-invasive neuromodulation techniques have garnered significant attention due to their great potential in treating brain disorders and inspecting brain functions. In particular, transcranial ultrasound has emerged as a novel therapeutic modality owing to its high spatiotemporal resolution and non-invasive nature. However, the therapeutic efficacy of conventional transcranial ultrasound for treating diseases remains relatively limited. To address this, we developed a baicalein-loaded nanocarrier (BP-B) capable of responsive release of nitric oxide gas upon ultrasonic stimulation, thereby temporarily opening the blood–brain barrier and enhancing the efficiency of intracerebral drug delivery. Furthermore, the production of nitric oxide amplifies the ultrasound-induced activation of cortical neurons. In a mouse model of Parkinson’s disease, deep brain stimulation of the subthalamic nucleus (STN) with ultrasound combined with BP-B treatment significantly improved motor and cognitive functions and alleviated parkinsonian symptoms without inducing notable toxicity. Collectively, this combined pharmacological and ultrasound modulation strategy provides a new approach for the non-invasive treatment of neurodegenerative diseases.

主办单位：生命科学技术学院

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